Health Professionals

The California Dried Plum Board sponsors nutrition and medical research that supports the role of dried plums in a balanced and health-promoting diet.

Dried Plum Polyphenols Attenuate the Detrimental Effects of TNF-a on Osteoblast Function Coincident with Up-regulation of Runx2, Osterix and IGF-1

07-02-2008

Journal of Nutritional Biochemistry DOI:10.1016/j.jnutbio.2007.11.012 Published online ahead of print May 20, 2008.
Bu, S.Y., Hunt, T.S., and Smith, B.J.

This cell culture study investigated how dried plum polyphenols and different concentrations ((0, 2.5, 5, 10 and 20 μg/ml) might influence osteoblast activity and mineralized nodule formation under normal and inflammatory conditions. Polyphenol doses of 5, 10 and 20 μg/ml enhanced the production of compounds linked to bone formation and countered the detrimental effects of TNF-a addition

Dried Plum Polyphenols Inhibit Osteoclastogenesis by Downregulating NFATc1 and Inflammatory Mediators.

07-02-2008

Calcified Tissue International (DOI 10.1007/s00223-008-9139-0).  Bu SY, Lerner M, Stoecker BJ, Boldrin E, Brackett DJ, Lucas EA and Smith BJ. 

This study investigated dried plum polyphenols' effect on osteoclast differentiation and activity in cell cultures.  Results of this study, combined with results of the authors' previous reports, suggest that the antiresorptive properties of dried plums observed in animal studies are in part mediated by polyphenols suppression of osteoclast differentiation and activity under normal, oxidative stress, and inflammatory conditions.

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